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Allopurinol

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1 Allopurinol on Thu Sep 01, 2016 12:25 pm

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Allopurinol: Natural Gout Treatment: the Results of a Gout

This is the second article of a series about this diet. Please see Natural Gout Treatment - The Rules Of A Gout Diet That Had A Lot Of Success, for the first article.

This study, based on the Zone diet, did have a positive effect on markers of insulin resistance: triglycerides, total cholesterol, LDL cholesterol ("bad" cholesterol) fell. HDL cholesterol ("good" cholesterol) did not fall. But my purpose in this article is mainly to describe its direct effect on uric acid levels and gout attacks.

The study can be found online if you search "Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study." Copy and paste this into a search engine search box and hit enter. Wink

Were the study albertus magnus college term medications, such as Allopurinol, for their gout? They were not. They were only taking medications for gout attacks. The study report did not say how much water they drank. Most gout vs pseudogout know that drinking lots of water helps to remove uric acid. In gout treatment there are always caveats. The study was small. Only 13 male gout sufferers. The study lasted just four months, although there were follow-up results after one year (median). The researchers noted a connection between weight loss and a fall in uric acid levels in another study and expected the nutrient proportions (40:30: contributed to the uric acid fall. They thought that the dietary measures caused the desired improvement in insulin sensitivity.

Note Especially that the Mean Uric Acid (UA) Fall Was

7mg/dL. In a couple of cases it fell by 2 mg/dL and by 5mg/dL respectively. Hyperuricemia, (excess uric acid), which may lead to gout, is reckoned to exist if the UA levels exceed 2 mg/dL (men), and 0 mg/dL (women). The usual UA target in gout treatment is 0 mg/dL (somewhat less in women) because at this level the MSU crystals, formed mainly from uric acid may dissolve. (It is the immune system's response to these crystals, which it regards as foreign bodies, which causes the pain and inflammation of gout).

AFTER ONE YEAR About a year later, five of nine patients had no diet for gouty arthritis and three had just one attack. So there was a further decrease in attack frequency overall. One patient gained weight after the end of the study. He must have given up on the diet. He suffered three attacks over three months. His blood uric acid levels rose with his weight.

So a fall of 1.7 mg/dL, given these numbers, is quite significant, although you should note that many gout sufferers have UA levels much higher than 7.2 mg/dL, and some gout sufferers do not have excess uric acid.


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  • One participant did not have a raised UA level before the start.
  • It was about 5.9mg/dL.
  • But we already know that gout can occur in people with normal uric acid levels, so this was not unusual.



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