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Pegloticase Continues Its Hopeful Path

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1 Pegloticase Continues Its Hopeful Path on Fri May 20, 2016 1:12 am

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In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels. There are no boundaries on countries for one to access information about Uric Acid Levels through the Internet. All one has to do is to surf, and then the required matter is availed!

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.



  • In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble.
  • This is achieved by drinking lots of water and by raising body pH levels in various ways.
  • You actually learn more about Normal Uric Acid Levels only with more reading on matters pertaining to it.
  • So the more articles you read like this, the more you learn about Normal Uric Acid Levels.







In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers. You must have searched high and low for some matter for Uric Acid, isn't it? That is the main reason we compiled this article for you to get that required matter!

Pegloticase's answer to the excess uric acid in blood problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase. It is not always that we just turn on the computer, and there is a page about Gout Sufferer. We have written this article to let others know more about Gout Sufferer through our resources. Embarassed

It has been having a decent degree of success

Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were donnelly college gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. Dallas baptist university gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove. Wink

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.



  • 31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial.
  • It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.
  • Now while reading about Gout Attacks, don't you feel that you never knew so much existed about Gout Attacks?
  • So much matter you never knew existed. Surprised





  • SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients.
  • The developing company has said that most were mild, moderate, or controllable.
  • But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.
  • Writing about Uric Acid Level is an interesting writing assignment.
  • There is no end to it, as there is so much to write about it!



This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension. Keep your mind open to anything when reading about Uric Acid Level. Opinions may differ, but it is the base of Uric Acid Level that is important. Evil or Very Mad



  • Please see Natural Gout Treatment - The Rules Of A Gout Diet That Had A Lot Of Success, for the first article.
    This is the second article of a series about this diet.





Note especially that the mean uric acid (UA) fall was

7mg/dL. In a couple of cases it fell by 2 mg/dL and by 5mg/dL respectively. Hyperuricemia, (excess uric acid), which may lead to gout, is reckoned to exist if the UA levels exceed 2 mg/dL (men), and 0 mg/dL (women). The usual UA target in gout treatment is 0 mg/dL (somewhat less in women) because at this level the MSU crystals, formed mainly from uric acid may dissolve. (It is the immune system's response to these crystals, which it regards as foreign bodies, which causes the pain and inflammation of gout).

The study can be found online if you search "Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study." Copy and paste this into a search engine search box and hit enter. Developing a gradual interest in Gout Attack was the basis for writing this article. On reading this, you will gradually get interested in Gout Attack. Shocked

This study, based on the Zone diet, did have a positive effect on markers of insulin resistance: triglycerides, total cholesterol, LDL cholesterol ("bad" cholesterol) fell. HDL cholesterol ("good" cholesterol) did not fall. But my purpose in this article is mainly to describe its direct effect on uric acid levels and gout attacks. Shocked

The results were sufficiently impressive to give hope and encouragement to any gout sufferer who tries this diet as accurately as possible. The study was conducted in 1999. Unfortunately it has not been followed up by a much larger one designed on the same lines. If conducted, such a study would expand our knowledge of natural gout treatment, perhaps considerably. Searching with regard to typical gout cures is what most gout sufferers want.

After four months on this diet the effects on uric acid levels and gout attacks were quite impressive. Weight loss and uric acid levels Weight loss over the period was almost 17lbs ( 7kg) i.e. at a rate of about 1lb a week. All but one of the patients lost weight. The median uric acid (UA) fall was 7mg/dL.Another very interesting finding was that a more elevated blood uric acid level at the start of the study, meant a large fall of blood uric acid by the end of it. Uric acid levels normalised in 7 of 12 patients who had raised levels of uric acid (UA) before the study. Laughing



  • AFTER ONE YEAR About a year later, five of nine patients had no more gout attacks and three had just one attack.
  • So there was a further decrease in attack frequency overall.
  • One patient gained weight after the end of the study.
  • He must have given up on the diet.
  • He suffered three attacks over three months.
  • His blood uric acid levels rose with his weight.
  • We tried to create as much matter for your understanding when writing on Gout Attack.
  • We do hope that the matter provided here is sufficient to you.





  • One participant did not have a raised UA level before the start.
  • It was about 5.9mg/dL.
  • But we already know that gout can occur in people with normal uric acid levels, so this was not unusual.



And gout attacks? Results overall were expressed as a median. Before the study, participants had at least two attacks in the preceding four months. Median monthly attacks before the study were After it, attacks fell to The fall in the number of gout attacks occurred in all except one patient. The exception participant had shorter and less severe attacks. Eight of the 13 did not have a gout attack during the four month study period, although as mentioned, they had all had at least two in the previous four months and, as noted above, the median was 1 a month, or one attack a fortnight, (every two weeks). Developing a vision on Excess Uric Acid, we saw the need of providing some enlightenment in Excess Uric Acid for others to learn more about Excess Uric Acid.

NB. The contents of this article contain medical information not medical advice. Please always discuss remedies with your doctor or other health care professional before implementing any treatment. Revision is very important when writing or speaking about a topic. We had a lot of drafting to do to come to this final product on Gout Diet.

In the study report, uric acid levels were expressed as mmol/l. In this article I have converted these mmol/l numbers to mg/dL, which is a more frequently used measurement. Gout Sufferers play a prominent part in this composition. It is with this prominence that we hope people get to know more about Gout Sufferers.

Were the study patients taking long term medications, such as Allopurinol, for their gout? They were not. They were only taking medications for gout attacks. The study report did not say how much water they drank. Most gout sufferers know that drinking lots of water helps to remove uric acid. In gout treatment there are always caveats. The study was small. Only 13 male gout sufferers. The study lasted just four months, although there were follow-up results after one year (median). The researchers noted a connection between weight loss and a fall in uric acid levels in another study and expected the nutrient proportions (40:30: contributed to the uric acid fall. They thought that the dietary measures caused the desired improvement in insulin sensitivity. After reading what was written here, don't you get the impression that you had actually heard about these points sometime back. Think back and think deeply about Gout.

Are cherries truly fruit for a healthy you? These day's people want to take care of themselves and tart cherries can help. Tart cherries naturally pack a health-promoting punch that provides pain relief for many people. Recent studies have revealed that tart (sour) cherries offer an assortment of health benefits including the ability to offer natural relief from joint pain caused from gout and other joint inflammation symptoms. Rolling Eyes

In an attempt to find relief from his pain, a friend recommended Fruit Advantage Tart Cherry capsules ***** "Within the first week of taking the tart cherry capsules my back felt so much better," says Mr. Roth. "I am now able to pick up my grandson without any pain in my back." Our objective of this article on Gout was to arouse your interest in it. Bring back the acquired knowledge of Gout, and compare it with what we have printed here.

Leading researchers believe that the pain relief may not come from a specific antioxidant in the cherries, but from the synergistic effect of all the natural compounds in cherries. The skin of the cherries holds most of the essential antioxidants vital to their health benefits. Antioxidants are vitamins, minerals and other compounds found naturally in everyday food, especially fruits and vegetables. There has been a gradual introduction to the world of Gout projected in this article. We had done this so that the actual meaning of the article will sink within you. Shocked

One significant source of tart cherry is Fruit Advantage Tart Cherry dietary supplement. The entire cherry, except the pit and stem, is used to make Fruit Advantage Tart Cherry -- even the skin. Just two capsules a day give you the benefits of this amazing fruit. Each daily serving provides 1200 mg of tart cherry. This amount equals the specific antioxidant benefits of over 5 glasses of cherry juice concentrate without he sugar.

Although more research is needed to unlock all of the amazing natural benefits of tart cherries, John Roth is a living testimony of the soothing affects of cherries on his joint pain. "After years of playing sports, my back always hurt. I was in so much pain I could barely get out of bed some days." says Roth. We were a bit tentative when embarking on this project on Gout. However, using the grit and determination we have, we have produced some fine reading material on Gout.

Some of the best known antioxidants include vitamin A, C and E

These powerful antioxidants fight free-radicals within the body and potentially slow down the natural oxidation process that occurs in the body. So with the increasing popularity of tart cherries, what should consumers look for in selecting tart cherry products? For best results, industry experts recommend consumers check the product label to make sure that it contains significant quantities of tart (sour) cherries.

As more people begin to experience joint pain due to gout and arthritis, many are searching for natural remedies to fight joint and muscle pain. With all of the options and conflicting information available on television, radio and the Internet, what is the best way to sift through all of the information? Although it can be a challenge, why curing gout naturally is safe, simple and effective really work are worth the time and effort. I have included some bullet proof information on the amazing benefits of tart cherries.

According to research from leading organizations, as few as twenty cherries can make a difference in relieving inflammation in the body. In addition, ongoing research points to the unique make-up of the compounds found in the tart cherry that helps to fight joint pain. So in other words, the compounds found in the tart cherry are natural pain inhibitors. In other words, tart cherries contain natural COX-1 and COX-2 inhibitors. In addition to fighting joint pain due to arthritis and gout, research also shows tart cherry juice helps to soothe sore muscles due to physical exercise. This article has been written with the intention of showing some illumination to the meaning of Gout Arthritis. This is so that those who don't know much about Gout Arthritis can learn more about it.

For years, the tart cherry has been the source of legend and folklore. The natural pain relieving properties has been handed down from generation to generation for natural joint pain relief. Just as the old saying goes, "an apple a day will keep the doctor away", tart cherry believers may soon be saying, "Twenty cherries day will keep the pain away".



  • Tart cherries are available in a variety of ways including fresh tart cherries, cherry juice concentrate and dried cherries.
  • One of the benefits of tart cherry juice concentrate is it takes approximately 100 cherries to make just one ounce of tart cherry juice.
  • So the tart cherry juice is a highly concentrated way to get your daily dose of cherries.
  • One source for tart cherry juice concentrate and tart cherry capsules is Traverse Bay Farms.
  • The company only specializes in super fruit-based products including tart cherry juice, dried tart cherries and more.

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